I am interested in how abnormal function of the default mode network (DMN) contributes to the clinical symptomaology of various neurological and psychiatric disorders. The existence of the DMN is a recent observation that has gained significant traction within the system neuroimaging field in part because heightened blood oxygen dependent (BOLD) signals (the blood flow alterations resolved by fMRI that are linked to neuronal potentials) within the DMN appears to corrupt activity within other functional networks responsible for producing a variety of behavior. Consequently, a variety of neurological (such Alzheimer's and Parkinson's Disease) and Psychiatric (such as Schizophrenia, Autism and ADHD) disease states have been linked with abnormal DMN activity.
I am currently funded under a K01 career development award through the National Institute of Mental Health (NIMH). Through this award, I am combining fMRI with both surface based electrocorticography (ECoG) and scalp based electroencephalography (EEG) recordings to characterize the functional dynamics of the DMN during active cognitive and resting states. Through these studies, we hope to better understand the natural physiology of the DMN possibly leading to a greater mechanistic understanding of how DMN contributes to disease.